Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells
A. B. Grenell, C. Singh, M. Raju, A. Wolk, S. Dalvi, G.-F. Jang, J. S. Crabb, C. E. Hershberger, K. V. Manian, J. W. Crabb, R. Singh, J. Du, B. Anand-Apte
This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.
bioRxiv · Jan 5, 2024Biochemistry