Author

J. K. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. Bhushan· 2 shared B. Willard· 2 shared C. Tam· 2 shared Y. Sun· 2 shared C. T. Lim· 1 shared F. Ghiamati· 1 shared G. Subramanian· 1 shared G.-F. Jang· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Bhushan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Epithelial cytokeratin 6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A

A. Bhushan, J. K. Chan, Y. Sun, F. Ghiamati, J. S. Crabb, G.-F. Jang, B. Willard, J. W. Crabb, C. Tam

This study shows that K6a restricts secretory autophagy of proinflammatory cytokines by interacting with Sec16A, reducing cytokine secretion in corneal epithelial cells.

bioRxiv · Jan 4, 2024 · PreprintCell Biology

Keratin 6a attenuates Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by suppressing ELKS/IKKϵ-dependent activation of NF-κB

J. K. Chan, Y. Sun, A. Bhushan, B. Willard, C. Tam

This study shows that keratin 6a suppresses TLR-triggered inflammation in corneal epithelial cells by modulating ELKS/IKKε-dependent NF-κB activation, preventing excessive cytokine and chemokine production.

bioRxiv · Oct 24, 2023 · PreprintImmunology

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum.

R. Chandramohanadas, R. Naidu, T. T. Chu, J. Tripathi, Y. Hu, G. Subramanian, J. X. Tong, P. Tripathi, K. Fang, K. S. Tan, C. T. Lim, J. K. Chan, Z. Bozdech

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

bioRxiv · Dec 2, 2019 · PreprintMicrobiology