Stabilization of a Protein by a Single Halogen-Based Aromatic Amplifier
K. E. Hage, N. B. Phillips, Y.-S. Chen, B. Dhayalan, J. Whittaker, K. Carr, L. Whittaker, M. H. Phillips, F. Ismail-Beigi, M. Meuwly, M. A. Weiss
This study demonstrates that halogenation of an aromatic ring in insulin stabilizes the protein and enhances its resistance to fibrillation and biological activity.
bioRxiv · Jul 25, 2022Biochemistry