S. Davies

Molecular characterisation of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022-23 UK upsurge

This study characterizes non-invasive Streptococcus pyogenes isolates from a 2022-23 UK scarlet fever upsurge, revealing strain diversity and genomic features associated with different infection types.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Sensing the rainbow: genetic and physiological responses to light quality in Ostreococcus, an ecologically important photosynthetic picoeukaryote

This study examines how light quality affects the transcriptome, pigments, and photophysiology of two Ostreococcus ecotypes, showing distinct responses based on their environmental origins.

Microbial Community Dynamics Provide Evidence for Hypoxia During a Coral Reef Mortality Event

The paper analyzes microbial community changes after a coral reef mortality event to infer hypoxia as a likely cause.

Microbial adaptation to venom is common in snakes and spiders

The paper identifies bacterial colonization in cobra venom that acquires genes counteracting venom antimicrobial peptides, challenging the sterility of venoms.

Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism

This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

The paper reports the structure of human MANEA and inhibitor complexes, revealing its mechanism and informing the development of antiviral agents against bovine viral diarrhea and dengue viruses.

Stability of extemporaneously compounded amiloride nasal spray

This study evaluates the stability of an extemporaneously compounded amiloride nasal spray over 7 days at room temperature, showing it remains physically, chemically, and microbiologically stable.

Multi-proxy evidence for the impact of the Storegga Slide Tsunami on the early Holocene landscapes of the southern North Sea

The paper identifies Storegga Slide tsunami deposits in the southern North Sea using seismic surveys, sediment cores, and dating methods, showing localized and temporary impacts.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

Genomic and epidemiological evidence of a dominant Panton-Valentine leucocidin-positive Methicillin Resistant Staphylococcus aureus lineage in Sri Lanka with spread to the United Kingdom and Australia

The paper conducts genomic analysis of MRSA in Sri Lanka, identifying a dominant PVL-positive ST5-MRSA-IVc lineage that spreads internationally.

Corals sustain growth but not skeletal density across the Florida Keys Reef Tract despite ongoing warming

This study examines coral growth and skeletal density across the Florida Keys Reef Tract over the past century, finding sustained extension rates but reduced skeletal density despite warming.