Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2 in Preclinical Animal Models
J.-G. Park, F. S. Oladunni, M. A. Rohaim, J. Whittingham-Dowd, J. Tollitt, B. M. Assas, W. Alhazmi, A. Almilaibary, M. Iqbal, P. Chang, R. Escalona, V. Shivanna, J. B. Torrelles, J. J. Worthington, L. H. Jackson-Jones, , M. Munir
This study evaluates an intranasal live-attenuated vaccine against SARS-CoV-2 in mice and hamsters, showing high immunogenicity and complete protection from disease and viral shedding.
bioRxiv · Jan 8, 2021Immunology