Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
S. Bhattacharyya, S. Bershtein, B. V. Adkar, J. Woodard, E. Shakhnovich
The paper investigates how point mutations in DHFR affect E. coli metabolism and phenotype by analyzing dTTP levels and enzyme kinetics.
bioRxiv · Dec 16, 2020Biophysics