S. Bhattacharyya

Medication Use is Associated with Distinct Microbial Features in Anxiety and Depression

This study links medication use to distinct gut microbial features in anxiety and depression, showing antidepressants have a larger effect on microbiota than diagnoses.

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon

This study maps 1225 protein-protein interactions in E. coli's 1-carbon metabolism pathway, revealing conserved interfaces that mediate transient interactions and enhance metabolic flux.

Morphological Reprogramming of Primary Cilia Length Mitigates the Fibrotic Phenotype in fibroblasts across diverse fibrotic conditions

The paper shows that altering primary cilia length in fibroblasts can reduce fibrotic responses across different fibrotic conditions.

3-epicaryoptin induces G2/M phase cell cycle arrest and apoptosis in human breast cancer cells by disrupting the microtubule network, an in vitro and in silico investigation

This study investigates 3-epicaryoptin's anti-cancer effects on MCF-7 cells, showing it induces G2/M arrest and apoptosis by disrupting microtubules.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Dynamics of membrane tubulation coupled with fission by a two-component module revealed on polymer cushioned bilayer islands

The paper uses polymer cushioned bilayer islands to study how BIN1 and Dyn2 interact to drive membrane tubulation and fission, revealing their coordinated roles in cellular processes.

Molecular basis of VEGFR1 autoinhibition at the plasma membrane

This study identifies a mechanism by which VEGFR1 remains constitutively inactive through juxtamembrane inhibition and phosphatase activity, explaining its differential regulation compared to VEGFR2.

Exogenous Recombinant N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B; ARSB) Inhibits Progression of B16F10 Cutaneous Melanomas and Modulates Cell Signaling

This study shows that exogenous ARSB treatment reduces B16F10 melanoma tumor size and improves survival by altering chondroitin sulfate levels and modulating cell signaling pathways.

Iron Memory in E. coli

This study shows E. coli remembers prior swarming experiences through iron levels, improving future swarming efficiency and affecting other behaviors like biofilm formation and antibiotic tolerance.

E-Protein Protonation Titration-induced Single Particle Chemical Force Spectroscopy for Microscopic Understanding and pI Estimation of Infectious DENV

The paper uses chemical force spectroscopy to measure the surface charge dynamics and estimate the isoelectric point of DENV-2 and DENV-4, showing consistency between experimental and theoretical results.

Evolution of mate harm resistance in females from Drosophila melanogaster populations selected for faster development and early reproduction

This study shows that female mate harm resistance decreases in Drosophila melanogaster populations selected for faster development and early reproduction, likely due to changes in breeding ecology and male trait evolution.

Influence of pump laser fluence on ultrafast structural changes in myoglobin

This study shows that varying pump laser fluence in TR-SFX experiments affects structural dynamics and coherent oscillations in myoglobin, highlighting the need for linear photoexcitation in ultrafast studies.

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.

Mechanistic analysis of a novel membrane-interacting variable loop in the pleckstrin-homology domain critical for dynamin function

This study investigates a novel variable loop in the dynamin PHD domain, showing that reduced hydrophobicity impairs membrane fission and CME, linking it to CMT neuropathy.

Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

The paper shows efflux promotes antibiotic resistance mutations by linking high efflux to reduced DNA repair, validated through a clinical resistome database and swarm experiments.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Mesenchymal Lineage Heterogeneity Underlies Non-Redundant Functions of Pancreatic Cancer-Associated Fibroblasts

The paper identifies a minor subset of pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) that have non-redundant functions in shaping the tumor microenvironment.

Constitutive expression of JASMONATE RESISTANT 1 elevates content of several jasmonates and primes Arabidopsis thaliana to better withstand drought

Constitutive expression of JAR1 primes Arabidopsis thaliana to better withstand drought stress by increasing JA-Ile content and altering adaptive systems.

E-cadherin regulates the stability and transcriptional activity of β-catenin in embryonic stem cells

This study shows E-cadherin stabilizes and activates β-catenin in mouse ESCs, influencing cell-state-dependent gene expression and differentiation.

Alpha-ketoglutarate augments prolyl hydroxylase-2 mediated inactivation of phosphorylated-Akt to inhibit induced-thrombosis and inflammation

This study shows that alpha-ketoglutarate inhibits Akt-driven thrombosis and inflammation by enhancing PHD2 activity and reducing pAkt1 levels in platelets and leukocytes.

One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases - Utah and Wisconsin, 2020

This study investigates SARS-CoV-2 infection and seropositivity in pets from households with confirmed human COVID-19 cases, finding that 17% of pets had neutralizing antibodies and suggesting transmission from humans to pets.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

A cancer cell-intrinsic GOT2-PPARδ axis suppresses antitumor immunity

This study identifies a cancer cell-intrinsic GOT2-PPARδ axis that suppresses antitumor immunity by restricting T cells and promoting immune-suppressive myeloid cells in PDAC.

Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype

The paper investigates how point mutations in DHFR affect E. coli metabolism and phenotype by analyzing dTTP levels and enzyme kinetics.

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

The paper identifies COVID-19 risk variants associated with gene expression in multiple immune cell types, revealing potential mechanisms linking genetic risk to disease severity.

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

Increased Expression of Chondroitin Sulfotransferases following AngII may Contribute to Pathophysiology Underlying Covid-19 Respiratory Failure: Impact may be Exacerbated by Decline in Arylsulfatase B Activity

This study shows Ang II increases chondroitin sulfotransferases and sulfated GAGs in vascular smooth muscle cells, which may enhance SARS-CoV-2 adherence and contribute to respiratory failure in Covid-19.

Megakaryopoiesis in Dengue virus infected K562 cell promotes viral replication which inhibits endomitosis and accumulation of ROS associated with differentiation

This study shows that DENV replication in PMA-induced differentiated K562 cells suppresses ROS accumulation and interferes with Megakaryopoiesis markers.

Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin Converting Enzyme 2 Receptor

This study investigates how thiol-disulfide balance affects the binding of SARS-CoV-2 spike protein to ACE2 using molecular dynamics simulations, showing reduced binding affinity when disulfide bonds are converted to thiols.