B. V. Adkar

Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon

This study maps 1225 protein-protein interactions in E. coli's 1-carbon metabolism pathway, revealing conserved interfaces that mediate transient interactions and enhance metabolic flux.

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

This study investigates how AMP substrate inhibition in adenylate kinase is modulated by domain motions, showing that inhibitory concentrations of AMP increase domain closure and affect catalytic activity.

Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype

The paper investigates how point mutations in DHFR affect E. coli metabolism and phenotype by analyzing dTTP levels and enzyme kinetics.

Substrate inhibition imposes fitness penalty at high protein stability

The paper shows that mutations increasing protein stability in E. coli adenylate kinase lead to substrate inhibition by AMP, reducing enzyme activity and fitness.

Accessibility of the Shine-Dalgarno sequence dictates N-terminal codon bias in E. coli

The paper shows that Shine-Dalgarno sequence accessibility affects N-terminal codon bias in E. coli by modulating translation initiation efficiency.

Tradeoffs between microbial growth phases lead to frequency-dependent and non-transitive selection

The paper models microbial growth phases to show how tradeoffs between growth, lag time, and yield lead to frequency-dependent and non-transitive selection.

Optimization of lag phase shapes the evolution of a bacterial enzyme

This study examines how mutations in E. coli's Adenylate Kinase affect growth phases, revealing that catalytic capacity optimizes lag time while growth rates are less affected.