Manipulating Histone Acetylation Leads to Adverse Effects in Hemangiosarcoma Cells
T. Suzuki, K. Aoshima, J. Yamazaki, A. Kobayashi, T. Kimura
This study investigates the effects of histone acetylation manipulation using HDACi and BETi on canine hemangiosarcoma cells, finding that SAHA and JQ1 induce apoptosis and anti-tumour immunity, while JQ1 inhibits proliferation.
bioRxiv · Dec 10, 2021 · PreprintCancer Biology