Connexin-43 dependent ATP release mediates macrophage activation during peritonitis
M. Dosch, J. Zindel, F. Jebbawi, N. Melin, D. Sanchez-Taltavull, D. Stroka, D. Candinas, G. Beldi
This study shows that Connexin-43-mediated ATP release from macrophages via TLR-2 and -4 agonists promotes sepsis severity, and inhibiting this pathway improves survival in peritonitis.
bioRxiv · Sep 23, 2018 · PreprintImmunology