Author

J.-B. Dupont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. L. Mack· 4 shared C. Lievre· 2 shared A. Bigot· 1 shared A. Bourdon· 1 shared A. Buj-Bello· 1 shared A. D. Hofemeier· 1 shared A. S. T. Smith· 1 shared B. J. Berry· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersPathology

D. L. Mack

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dystrophin deficiency impairs cell junction formation during embryonic myogenesis

E. Mozin, E. Massourides, V. Mournetas, C. Lievre, A. Bourdon, D. L. Jackson, J. S. Packer, J. Seong, C. Trapnell, C. Le Guiner, O. Adjali, C. Pinset, D. L. Mack, J.-B. Dupont

This study shows that dystrophin deficiency disrupts cell junction formation during embryonic myogenesis in human pluripotent stem cells.

bioRxiv · Dec 5, 2023 · PreprintPathology

Dystrophin is a mechanical tension modulator

A. D. Hofemeier, M. Ristau, M. Luber, T. M. Muenker, F. Herkenrath, B. Schmelz, L.-M. Scharfenstein, M. Brandt, P. Malova, M. Shahriyari, M. Rinn, D. Haertter, M. Tiburcy, W. H. Zimmermann, C. Lenz, , T. Betz

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

bioRxiv · Dec 23, 2022 · PreprintBiophysics

High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing

A. S. T. Smith, S. M. Luttrell, J.-B. Dupont, K. Gray, D. Lih, J. W. Fleming, N. J. Cunningham, S. Jepson, J. Hesson, J. Mathieu, L. Maves, B. J. Berry, E. C. Fisher, N. Sniadecki, N. A. Geisse, D. L. Mack

This paper introduces a magnetic sensing system for real-time monitoring of engineered skeletal muscle function, showing improved contractility over time and enabling drug screening and disease modeling.

bioRxiv · May 20, 2022Bioengineering

AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathy

J.-B. Dupont, J. Guo, M. W. Lawlor, R. W. Grange, J. T. Gray, A. Buj-Bello, M. K. Childers, D. L. Mack

The paper uses RNA-sequencing to analyze the transcriptome of canine XLMTM muscle after rAAV8-cMTM1 gene transfer, showing dose-dependent normalization of gene expression and identifying new disease-related transcripts.

bioRxiv · Dec 17, 2018Pathology