Author

J.-E. Shea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

K. S. Kosik· 2 shared S. Han· 2 shared A. Dubose· 1 shared A. P. Longhini· 1 shared G. H. Fredrickson· 1 shared J. McCarty· 1 shared J. N. Rauch· 1 shared K. T. Delaney· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

K. S. Kosik

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2 papers

Recent·Most cited

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

M. Vigers, S. Lobo, S. Najafi, A. Dubose, K. Tsay, P. Ganguly, A. P. Longhini, Y. Jin, S. K. Buratto, K. S. Kosik, M. S. Shell, J.-E. Shea, S. Han

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

bioRxiv · Nov 28, 2023 · PreprintBiophysics

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

Y. Lin, J. McCarty, J. N. Rauch, K. T. Delaney, K. S. Kosik, G. H. Fredrickson, J.-E. Shea, S. Han

This study identifies the narrow conditions under which tau and RNA form reversible coacervates and fibrils, revealing entropy-driven LLPS under physiological conditions.

bioRxiv · Sep 22, 2018Biophysics