Author

K. S. Kosik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. Han· 4 shared Y. Lin· 3 shared A. P. Longhini· 2 shared J.-E. Shea· 2 shared A. Apostolaki· 1 shared A. Dubose· 1 shared E. Guzman· 1 shared G. C. Bazan· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersBiophysics

S. Han

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Author profile →

5 papers

Recent·Most cited

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

M. Vigers, S. Lobo, S. Najafi, A. Dubose, K. Tsay, P. Ganguly, A. P. Longhini, Y. Jin, S. K. Buratto, K. S. Kosik, M. S. Shell, J.-E. Shea, S. Han

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

bioRxiv · Nov 28, 2023 · PreprintBiophysics

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Y. Lin, Y. Fichou, A. P. Longhini, L. C. Llanes, Y. Yin, G. C. Bazan, K. S. Kosik, S. Han

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

bioRxiv · Aug 5, 2020Biophysics

Cell population effects in a mouse tauopathy model identified by single cell sequencing

V. Lisi, G. Luna, A. Apostolaki, M. Giroux, K. S. Kosik

The paper identifies cell population effects in a mouse tauopathy model using single-cell sequencing, finding size reduction and gene expression changes in granule cell neurons before tau inclusions appear.

bioRxiv · Sep 16, 2019 · PreprintCell Biology

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

Y. Lin, J. McCarty, J. N. Rauch, K. T. Delaney, K. S. Kosik, G. H. Fredrickson, J.-E. Shea, S. Han

This study identifies the narrow conditions under which tau and RNA form reversible coacervates and fibrils, revealing entropy-driven LLPS under physiological conditions.

bioRxiv · Sep 22, 2018Biophysics

RNA Stores Tau Reversibly in Complex Coacervates

X. Zhang, Y. Lin, N. A. Eschmann, H. Zhou, J. Rauch, I. Hernandez, E. Guzman, K. S. Kosik, S. Han

This paper shows tau protein forms liquid droplets with RNA, specifically tRNAs, through complex coacervation, and prolonged droplet residency can lead to beta-sheet formation and aggregation.

bioRxiv · May 7, 2017Biophysics