Author

A. P. Longhini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

K. S. Kosik· 2 shared S. Han· 2 shared A. Dubose· 1 shared G. C. Bazan· 1 shared J.-E. Shea· 1 shared K. Tsay· 1 shared L. C. Llanes· 1 shared M. S. Shell· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

K. S. Kosik

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

M. Vigers, S. Lobo, S. Najafi, A. Dubose, K. Tsay, P. Ganguly, A. P. Longhini, Y. Jin, S. K. Buratto, K. S. Kosik, M. S. Shell, J.-E. Shea, S. Han

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

bioRxiv · Nov 28, 2023 · PreprintBiophysics

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Y. Lin, Y. Fichou, A. P. Longhini, L. C. Llanes, Y. Yin, G. C. Bazan, K. S. Kosik, S. Han

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

bioRxiv · Aug 5, 2020Biophysics