Dermatan Sulfate Is a Potential Master Regulator of IgH via Interactions with Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts
J. Lee, J.-h. Rho, M. H. Roehrl, J. Y. Wang
This study identifies dermatan sulfate (DS) as a master regulator of IgH in pre-B cells by interacting with pre-BCR components, GTF2I, and ER proteins, influencing autoreactive B cell development and autoimmunity.
bioRxiv · Jan 18, 2021Immunology