J. Y. Wang

Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escape

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

Chromosome-scale pearl millet genomes reveal a CARLACTONOIC ACID METHYL TRANSFERASE as key determinant of strigolactone pattern and Striga susceptibility

The paper identifies a CLAMT1 gene responsible for strigolactone production and Striga susceptibility in pearl millet by comparing genome assemblies of susceptible and resistant lines.

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.

Zaxinone Synthase overexpression modulates rice physiology and metabolism, improving growth and productivity under normal and low phosphate supply

This study shows that overexpressing Zaxinone Synthase in rice increases zaxinone levels, enhances growth, and improves phosphate uptake, leading to higher grain yield.

Abscisic acid inhibits germination of Striga seeds and is released by them as a rhizospheric signal providing competitive advantage and supporting host infestation

This study shows that abscisic acid (ABA) inhibits Striga seed germination but is released by germinated seeds as a rhizospheric signal to enhance competitive advantage and host infestation.

Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome

This study identifies intrinsic AT2 progenitor dysfunction and p53 pathway dysregulation as novel mechanisms driving pulmonary fibrosis in Hermansky-Pudlak syndrome.

Disruption of the rice 4-DEOXYOROBANCHOL HYDROXYLASE unravels specific functions of canonical strigolactones

This study identifies the role of OsMAX1-1400 in rice by showing its specific contribution to canonical strigolactone biosynthesis and its impact on plant architecture and rhizospheric interactions.

Integration of Apocarotenoid Profile and Expression Pattern of Carotenoid Cleavage Dioxygenases during Mycorrhization in Rice

The paper profiles apocarotenoids and CCD gene expression in rice during AM symbiosis and phosphate conditions, identifying novel markers.

Genome expansion by a CRISPR trimmer-integrase

The paper identifies a CRISPR trimmer-integrase that processes DNA for integration in the absence of Cas4, using cryo-EM structures to show its mechanism.

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

ZAXINONE SYNTHASE 2 regulates growth and arbuscular mycorrhizal symbiosis in rice

This study identifies OsZAS2 as a zaxinone-forming enzyme in rice that regulates growth, development, and arbuscular mycorrhizal symbiosis.

The Arabidopsis D27like1 is a novel Isomerase that Contributes to SL Biosynthesis and Negatively Impacts ABA Level

This paper identifies AtD27-like1 as a cis/cis-{beta}-carotene isomerase that contributes to strigolactone biosynthesis and negatively affects ABA levels in Arabidopsis.

Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

This study shows canonical strigolactones in rice are not responsible for shoot branching inhibition but act as rhizospheric signals to influence Striga germination and mycorrhizal colonization.

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

A Master Autoantigen-ome Links Alternative Splicing, Female Predilection, and COVID-19 to Autoimmune Diseases

The paper identifies a master autoantigen-ome linking alternative splicing, female predilection, and COVID-19 to autoimmune diseases through analysis of 751 autoantigens across six human cell types.

An Autoantigen Profile from Jurkat T-Lymphoblasts Provides a Molecular Guide for Investigating Autoimmune Sequelae of COVID-19

This study identifies 140 autoantigens from Jurkat T-cells, showing 75% are autoantibody targets and 89% are altered in SARS-CoV-2 infection, linking them to autoimmune and cancer-related pathways.

An Autoantigen-ome from HS-Sultan B-Lymphoblasts Offers a Molecular Map for Investigating Autoimmune Sequelae of COVID-19

This study identifies 362 autoantigens from HS-Sultan B-lymphoblasts, showing 87% are affected by SARS-CoV-2 infection, offering insights into COVID-19-induced autoimmunity.

An Autoantigen Profile of Human A549 Lung Cells Reveals Viral and Host Etiologic Molecular Attributes of Autoimmunity in COVID-19

This study identifies 348 autoantigens from human A549 lung cells, revealing viral and host factors involved in autoimmunity during SARS-CoV-2 infection.

An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19

The study identifies an autoantigenome from human lung HFL1 cells using dermatan sulfate affinity, linking it to neurological and autoimmune complications of COVID-19.

Dermatan Sulfate Is a Potential Master Regulator of IgH via Interactions with Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts

This study identifies dermatan sulfate (DS) as a master regulator of IgH in pre-B cells by interacting with pre-BCR components, GTF2I, and ER proteins, influencing autoreactive B cell development and autoimmunity.

The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis

This study identifies the lncRNA PLANE as a regulator of alternative splicing that promotes cancer progression by repressing NCOR2-202 splicing, leading to poor patient outcomes.

Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1--Cas2 CRISPR integrase complex

The paper determines the cryo-EM structure of a Cas6-RT-Cas1-Cas2 complex and shows bidirectional and unidirectional crosstalk between its active sites.

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

Engineering Plant Architecture via CRISPR/Cas9-mediated Alteration of Strigolactone Biosynthesis

This study uses CRISPR/Cas9 to disrupt CCD7 in rice, altering strigolactone biosynthesis and resulting in increased tillering and a dwarf phenotype.

Nuclear Abl Drives miR-34c Transfer by Extracellular Vesicles to Induce Radiation Bystander Effects

The paper shows that nuclear Abl drives miR-34c secretion via extracellular vesicles, which induce ROS and DNA damage in non-irradiated cells, causing radiation bystander effects.