The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
C. Körner, J.-H. Schäfer, B. M. Esch, K. Parey, S. Walter, D. Teis, D. Januliene, O. Schmidt, A. Moeller, F. Fröhlich
The paper determines the cryo-EM structure of the SPT-Orm2 complex and shows Orm2 has higher inhibitory potential than Orm1, despite similar structures.
bioRxiv · Jan 30, 2024Biochemistry