Author

J.-L. Mergny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. Islam· 2 shared J. Sponer· 2 shared M. Otyepka· 2 shared P. Stadlbauer· 2 shared C. Gonzalez Ibanez· 1 shared D. Maiorano· 1 shared D. Monchaud· 1 shared E. Istvankova· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

B. Islam

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DNA i-motif levels are overwhelmingly depleted in living human cells: insights from in-cell NMR.

P. Viskova, E. Istvankova, J. Rynes, S. Dzatko, T. Loja, M. Lenarcic Zivkovic, R. Rigo, R. El Khoury, I. Serrano-Chacon, M. J. Damha, C. Gonzalez Ibanez, J.-L. Mergny, S. Foldynova-Trantirkova, L. Trantirek

The paper uses in-cell NMR to study DNA i-motif formation in human cells, finding that i-motifs are rare and cell cycle-dependent.

bioRxiv · Oct 1, 2023 · PreprintBiophysics

Identification and Characterisation of Proteins Binding to a G-Quadruplex Origin G-rich Repeated Element in Mammalian Cells

J. R. A. Hutchins, I. Peiffer, S. Urbach, J.-L. Mergny, P. Marin, D. Maiorano, M. MECHALI

The paper identifies proteins that bind to an OGRE element in mammalian cells and shows their role in DNA synthesis by affecting the cell cycle.

bioRxiv · Mar 30, 2023 · PreprintCell Biology

Insights into G-Quadruplex-Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding

P. Stadlbauer, B. Islam, M. Otyepka, J. Chen, D. Monchaud, J. Zhou, J.-L. Mergny, J. Sponer

This study uses atomistic simulations to investigate G4-hemin interactions, revealing dynamic binding mechanisms and suggesting hemin's role in G4 folding.

bioRxiv · Nov 9, 2020Biophysics

Stability of Two-quartet G-quadruplexes and Their Dimers in Atomistic Simulations

B. Islam, P. Stadlbauer, M. Vorlickova, J.-L. Mergny, M. Otyepka, J. Sponer

This study uses molecular dynamics simulations to investigate the stability of two-quartet and four-quartet G-quadruplexes, finding that three quartets are needed for stable DNA GQs and RNA two-quartet GQs are weakly stable.

bioRxiv · Feb 25, 2020Biophysics