S. Urbach

Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

The paper uses NMR, molecular dynamics, and pharmacology to study conformational changes in the V2R receptor bound to different ligands, revealing a mechanism for Gs-biased agonism involving TM7 and TM3 interactions.

Convergent origin and accelerated evolution of vesicle-associated RhoGAP proteins in two unrelated parasitoid wasps

The paper identifies convergent evolution and accelerated positive selection of vesicle-associated RhoGAP proteins in two parasitoid wasp species, showing loss of GAP activity and GTPase binding.

Identification and Characterisation of Proteins Binding to a G-Quadruplex Origin G-rich Repeated Element in Mammalian Cells

The paper identifies proteins that bind to an OGRE element in mammalian cells and shows their role in DNA synthesis by affecting the cell cycle.

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

This study shows SLX4 forms membraneless compartments that regulate SUMO-RNF4 pathway activity and DNA repair processes.

Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

This study shows that Fibromodulin from non-cancer stem cells promotes glioma tumor growth by activating Notch signaling in endothelial cells through integrin-dependent paracrine signaling.

An apical membrane complex controls rhoptry exocytosis and invasion in Toxoplasma

The paper identifies CRMPs as a complex involved in rhoptry exocytosis and invasion in Toxoplasma, acting as a host-molecular sensor.

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

The paper reports the cryo-EM structure of the V2 receptor-{beta}-arrestin1 complex, revealing structural variability in GPCR-arrestin interactions.

The beta-tubulin isotype TUBB6 controls microtubule and actin dynamics in osteoclasts.

This study shows that TUBB6 regulates microtubule and actin dynamics in osteoclasts, affecting bone resorption through its control of ARHGAP10 and CDC42.

SHED-dependent oncogenic signalling of the PEAK3 pseudo-kinase

This study identifies PEAK3 as an oncogenic pseudo-kinase that uses the SHED module to activate AKT signaling and promote cancer growth.

TopBP1 assembles nuclear condensates to switch on ATR signalling.

This study shows TopBP1 forms condensates to activate ATR signaling, which phosphorylates Chk1 and slows replication forks.

Primary myeloid cell proteomics and transcriptomics: importance of β tubulin isotypes for osteoclast function.

This study provides proteomic and transcriptomic data of primary myeloid cells, identifying Tubb6 as a key regulator of osteoclast function through podosome organization and bone resorption.

Inheritance of Chromatin Proteins in Budding Yeast: metabolic gene regulators TUP1, FPR4 and Rpd3L are retained in the mother cell.

The paper investigates chromatin protein inheritance in budding yeast, finding that some proteins are retained in the mother cell during asymmetric division.

Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation

This study identifies a dimerization mechanism in the pseudo-kinase Pragmin that regulates protein tyrosine phosphorylation through interaction with CSK.

Initiation of DNA replication requires actin dynamics and formin activity

The paper shows that actin dynamics and formin activity are essential for DNA replication and nuclear transport in human cells and Xenopus egg extracts.