Author

J.-P. Mecklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Ahadova· 1 shared A. B. Riemer· 1 shared A. Ballhausen· 1 shared A. Benner· 1 shared A. Lepistö· 1 shared D. Heid· 1 shared E. K. Laakkonen· 1 shared E. Pfaffendorf· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Ahadova

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2 papers

Recent·Most cited

Systemic circulating microRNA landscape in Lynch syndrome

T. Sievänen, T.-M. Korhonen, T. Jokela, M. Ahtiainen, L. Lahtinen, T. Kuopio, A. Lepistö, E. Sillanpää, J.-P. Mecklin, T. T. Seppälä, E. K. Laakkonen

This study identifies circulating miRNA signatures in Lynch syndrome carriers that distinguish them from non-carriers but not from cancer patients, suggesting potential for monitoring oncogenic stress in cancer-free individuals.

bioRxiv · Mar 10, 2022Cancer Biology

The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution

A. Ballhausen, M. J. Przybilla, M. Jendrusch, S. Haupt, E. Pfaffendorf, M. Draxlbauer, F. Seidler, S. Krausert, A. Ahadova, M. S. Kalteis, D. Heid, J. Gebert, M. Bonsack, S. Schott, H. Bläker, , M. Kloor

The study identifies shared immunogenic neoantigens in MSI cancers and finds a negative correlation between indel mutation frequency and neoantigen immunogenicity, suggesting immunoediting during tumor evolution.

bioRxiv · Jul 16, 2019Cancer Biology