S. Haupt

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

This paper develops a computational model to simulate colonic crypt evolution in Lynch syndrome, showing the importance of stem cell dynamics and MMR deficiency in CRC development.

Genome-wide CRISPR screens reveal APR-246 (Eprenetapopt) triggers ferroptosis and inhibits iron-sulfur cluster biogenesis

This paper identifies APR-246's mechanism of inducing ferroptosis and inhibiting iron-sulfur cluster biogenesis through cysteine conjugation in mutant-p53 cancer cells.

SLC7A11 is a superior determinant of APR-246 (Eprenetapopt) response than TP53 mutation status

This study identifies SLC7A11 expression as a better predictor of response to APR-246 than TP53 mutation status using cell line data and functional validation.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Mathematical Modeling of Multiple Pathways in Colorectal Carcinogenesis using Dynamical Systems with Kronecker Structure

This paper develops a dynamical system model with Kronecker structure to simulate colorectal carcinogenesis pathways in Lynch syndrome, enabling mathematical analysis of tumor evolution and mutation dynamics.

MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer.

This study evaluates MDM2 inhibition combined with endocrine therapy and CDK4/6 inhibition in ER-positive breast cancer, showing synergistic anti-tumor effects in resistant models.

The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution

The study identifies shared immunogenic neoantigens in MSI cancers and finds a negative correlation between indel mutation frequency and neoantigen immunogenicity, suggesting immunoediting during tumor evolution.