Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis
B. D. Adair, J. L. Alonso, J. van Agthoven, V. Hayes, H. S. Ahn, I.-S. Yu, S.-W. Lin, M. Poncz, J.-P. Xiong, M. A. Arnaout
This study designs a novel orthosteric inhibitor of integrin αIIbβ3 that prevents thrombosis without impairing hemostasis, using structure-guided methods.
bioRxiv · Apr 25, 2019 · PreprintCell Biology