M. Poncz

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.

Packaging of supplemented urokinase into naked alpha-granules of in vitro-grown megakaryocytes for targeted therapeutic delivery

The paper demonstrates that in vitro-grown megakaryocytes can store exogenous uPA in alpha-granules, which can be used to generate anti-thrombotic human platelets that lyse nascent thrombi in a mouse model.

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

This study shows that stabilizing neutrophil extracellular traps (NETs) with platelet factor 4 reduces thrombogenicity and endothelial cell injury in sepsis.

Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?

This paper demonstrates that deglycosylated KKO (DGKKO) can prevent and reverse thrombocytopenia and thrombosis in a HIT murine model.

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects in an in vivo murine model: Therapeutic implications

This paper shows that RUNX1-deficient human megakaryocytes have thrombopoietic and platelet defects in mice, which can be reversed by a TGFβ inhibitor.

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Neutrophil extracellular trap stabilization leads to improved outcomes in murine models of sepsis

This study shows that stabilizing neutrophil extracellular traps (NETs) with PF4 and KKO improves outcomes in sepsis by reducing NET degradation products and enhancing bacterial capture.

Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis

This study designs a novel orthosteric inhibitor of integrin αIIbβ3 that prevents thrombosis without impairing hemostasis, using structure-guided methods.