M. A. Arnaout

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

Structure-guided design of novel orthosteric inhibitors of integrin αIIbβ3 that prevent thrombosis but preserve hemostasis

This study designs a novel orthosteric inhibitor of integrin αIIbβ3 that prevents thrombosis without impairing hemostasis, using structure-guided methods.