Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS
J.-Q. Liu, H. Liu, Y. Li, X. Liu, L.-Q. Wang, K. Wang, Z. Yang, Q. Fu, X. Xu, J. Chen, Y. Zhang, J. Zhou, W. Le, M. Cui, Y. Liang
This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.
bioRxiv · Mar 16, 2024Biochemistry