SMAD4 and TGFβ are architects of inverse genetic programs during fate-determination of antiviral memory CD8 T cells
K. Chandiran, J. Suarez-Ramirez, Y. Hu, Z. Ugur, E. R. Jellison, J.-S. low, B. McDonald, S. M. Kaech, L. S. Cauley
This study shows SMAD4 and TGFβ regulate gene expression in opposite ways to determine whether antiviral CD8 T cells become circulating or tissue-resident memory cells.
bioRxiv · Dec 16, 2021Immunology