S. M. Kaech

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

SMAD4 and TGFβ are architects of inverse genetic programs during fate-determination of antiviral memory CD8 T cells

This study shows SMAD4 and TGFβ regulate gene expression in opposite ways to determine whether antiviral CD8 T cells become circulating or tissue-resident memory cells.

Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults

This study identifies shared and seasonal molecular signatures of influenza vaccination in young and older adults, revealing age-specific gene expression patterns linked to antibody responses.