Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and mice
Judith W. Hyle, Zhenling Liu, Shaela Fields, Jifeng Yang, Xinyan Chen, Wenjie Qi, Qiong Zhang, Byoung-Kyu Cho, Young Ah Goo, Xiuling Li, Jack E. Sublett, Qianqian Li, Liusheng He, Jonathon D. Klein, Peng Xu, , Chunliang Li
This study identifies four resistance mechanisms to sustained auxin-inducible protein degradation in human cells and mice using the AID2 system.
bioRxiv · Sep 21, 2025 · PreprintCell Biology