BoltzGen: Toward Universal Binder Design
Hannes Stark, Felix Faltings, MinGyu Choi, Yuxin Xie, Eunsu Hur, Timothy J. O’Donnell, Anton Bushuiev, Talip Uçar, Saro Passaro, Weian Mao, Mateo Reveiz, Roman Bushuiev, Tally Portnoi, Tomáš Pluskal, Josef Šivic, , Tommi Jaakkola
An all-atom diffusion model unifying biomolecular structure prediction and sequence-structure generation designs experimentally validated nanobodies, mini-proteins, and linear or cyclic peptides across 26 diverse targets.
bioRxiv · Nov 20, 2025 · PreprintBioengineering✦ In-depth digest