Andrew Savinov

AI-discovered protein fragments as generalizable regulators of biomolecular condensates

This study uses AI to design protein fragments that regulate biomolecular condensates, showing success in multiple targets and revealing new interaction mechanisms.

BoltzGen: Toward Universal Binder Design

An all-atom diffusion model unifying biomolecular structure prediction and sequence-structure generation designs experimentally validated nanobodies, mini-proteins, and linear or cyclic peptides across 26 diverse targets.

Effects of sequence motifs in the yeast 3' untranslated region determined from massively-parallel assays of random sequences

The paper assesses the functional impact of sequence motifs in yeast 3' UTRs using random sequence libraries, revealing context-dependent regulatory effects.