David M. Sabatini

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

An all-atom diffusion model unifying biomolecular structure prediction and sequence-structure generation designs experimentally validated nanobodies, mini-proteins, and linear or cyclic peptides across 26 diverse targets.

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

This study identifies lysosomal RNases and shows specific RNA types are targeted for degradation via autophagy-dependent mechanisms.

This study shows that MFSD12 is essential for mouse embryonic development by supplying reduced cysteine to lysosomes, and cysteamine treatment rescues Mfsd12 knockout mice.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

The paper identifies mTOR-activating mutations in RRAGD causing kidney tubulopathy and cardiomyopathy (KICA) syndrome through genetic and functional analyses of patient cohorts.

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

The paper introduces MITO-Tag Mice to isolate mitochondria from specific cell types in vivo and identifies mitochondrial metabolite changes during fasting and refeeding in hepatocytes.

The paper identifies juxtacap nucleotide sequences that modulate eIF4E binding and translation, showing context-dependent effects on ribosome occupancy and translation efficiency.