Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease
Yubing Liu, Bensun C. Fong, Richard A. Harris, Marie-Michelle McNicoll, Amaal A. Abdi, Jacob B. Cuthbert, David P. Cook, Daniel Figeys, Jing Wang, Barbara C. Vanderhyden, Ruth S. Slack
The paper uses single-cell RNA-Seq to study neural stem cell (NSC) defects in 3xTG-AD mice, finding reduced NSC activation and impaired neurogenesis linked to AD pathology.
bioRxiv · Jun 8, 2022 · PreprintNeuroscience