Barbara C. Vanderhyden

Preventing surgery induced immune suppression and metastases by inhibiting PI3K-gamma signalling in Myeloid-Derived Suppressor Cells.

The paper identifies PI3K-gamma signaling as a key pathway in surgery-induced MDSCs that suppresses NK cells and promotes metastases, showing that targeting this pathway can reduce postoperative metastases.

BRCA mutation alters the stromal landscape in normal ovaries

This study shows BRCA mutations alter ovarian stromal structure by promoting fibroblast senescence and myofibroblastic transformation, creating a metastatic niche for early ovarian cancer.

Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease

The paper uses single-cell RNA-Seq to study neural stem cell (NSC) defects in 3xTG-AD mice, finding reduced NSC activation and impaired neurogenesis linked to AD pathology.