Author

Ruth S. Slack

University of OttawaORCID 0000-0002-1552-2835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Alvin P. JoseliniD· 2 shared Bensun C. FongiD· 2 shared Daniel FigeysiD· 2 shared David P. CookiD· 2 shared David S. ParkiD· 2 shared Alena KalininaiD· 1 shared Amaal A. Abdi· 1 shared Barbara C. VanderhydeniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Alvin P. JoselinORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

VDAC1 regulates stress-associated matrix localization of DJ-1 to support mitochondrial homeostasis and neuronal survival

Jéssica Taday, Doo Soon Im, Sarah J. Hewitt, Gaurav Kaushik, Steve M. Callaghan, Ujval Anilkumar, Marisa Brini, Daniel Figeys, Zafran Khan, Nargis Khan, Ruth S. Slack, David S. Park, Alvin P. Joselin

This study identifies VDAC1 as a regulator of DJ-1's mitochondrial matrix localization, showing its role in maintaining mitochondrial homeostasis and neuronal survival under stress.

bioRxiv · Sep 1, 2026 · PreprintNeuroscience

Mitotic Activity and DNA Maintenance of Adult Neural Stem Cells is Regulated by Beclin1

Alena Kalinina, Jasbir Dhaliwal, Y Xue, Michael Vaculik, M. McCambley, Bensun C. Fong, David P. Cook, Ruth S. Slack, Diane C. Lagace

This study shows Beclin1 is required for mitosis and DNA maintenance in adult neural stem cells, leading to reduced neurogenesis.

bioRxiv · Jan 26, 2024 · PreprintNeuroscience

sncRNAP: Prediction and profiling of full sncRNA repertoires from sRNAseq data

Hesham A. Y. Gibriel, Sharada Baindoor, Ruth S. Slack, Jochen H.M. Prehn

sncRNAP profiles and identifies differentially expressed sncRNAs from sRNAseq data, identifying potential disease biomarkers in hepatitis and PDAC datasets.

bioRxiv · May 23, 2023 · PreprintBioinformatics

Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimers Disease

Yubing Liu, Bensun C. Fong, Richard A. Harris, Marie-Michelle McNicoll, Amaal A. Abdi, Jacob B. Cuthbert, David P. Cook, Daniel Figeys, Jing Wang, Barbara C. Vanderhyden, Ruth S. Slack

The paper uses single-cell RNA-Seq to study neural stem cell (NSC) defects in 3xTG-AD mice, finding reduced NSC activation and impaired neurogenesis linked to AD pathology.

bioRxiv · Jun 8, 2022 · PreprintNeuroscience

PFTK1 kinase regulates axogenesis during development via RhoA activation.

Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar‐Nejad, Suzi Wang, Dianbo Qu, Leticia Sánchez-Alvarez, Dina Hawari, Margaret J. Sonnenfeld, Ruth S. Slack, Paul R. Albert, David S. Park, Alvin P. Joselin

This study identifies PFTK1's role in axogenesis by regulating RhoA phosphorylation and activity during CNS development in Drosophila and mice.

bioRxiv · Jan 11, 2022 · PreprintNeuroscience