Author

Jacob B. Wolpe

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adrian HalmeiD· 2 shared Jacob S. Jaszczak· 2 shared André L. Martins· 1 shared Anh Q. Dao· 1 shared Michael J. GuertiniD· 1 shared Rajan BhandariiD· 1 shared Rebecca G. Jaszczak· 1 shared

Activity by Year

2015-2022 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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2 shared papersDevelopmental Biology

Adrian HalmeORCID

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3 papers

Recent·Most cited

Correction of transposase sequence bias in ATAC-seq data with rule ensemble modeling

Jacob B. Wolpe, André L. Martins, Michael J. Guertin

The paper develops a rule ensemble machine learning method to correct Tn5 transposase sequence bias in ATAC-seq data, improving the interpretation of chromatin accessibility.

bioRxiv · Dec 8, 2022 · PreprintBioinformatics

The relaxin receptor Lgr3 mediates growth coordination and developmental delay during Drosophila melanogaster imaginal disc regeneration

Jacob S. Jaszczak, Jacob B. Wolpe, Rajan Bhandari, Rebecca G. Jaszczak, Adrian Halme

This study shows that Lgr3 mediates Dilp8-dependent growth coordination and developmental delay during Drosophila imaginal disc regeneration by regulating NOS activation in the prothoracic gland and CNS.

bioRxiv · Nov 21, 2015 · PreprintDevelopmental Biology

Nitric oxide regulates growth coordination during regeneration

Jacob S. Jaszczak, Jacob B. Wolpe, Anh Q. Dao, Adrian Halme

This study shows nitric oxide regulates growth coordination during Drosophila regeneration by modulating ecdysone biosynthesis in the prothoracic gland.

bioRxiv · Mar 6, 2015Developmental Biology