Rajan Bhandari

The paper demonstrates that anti-CD206 CAR T cells restore dermal white adipose tissue in systemic sclerosis by targeting CD206+ macrophages and reversing their effects on adipose-derived stem cells.

The paper characterizes single-cell transcriptomic and epigenomic features of a 3D skin-like model of systemic sclerosis, identifying fibroblast subpopulations and their interactions with macrophages.

The paper shows ecdysone has a dual role in Drosophila regeneration, promoting it at low concentrations and suppressing it at high concentrations, coordinating regeneration with development.

The paper shows that ecdysone regulates the epithelial barrier in Drosophila imaginal discs, limiting Dilp8 signaling and controlling the duration of the regeneration checkpoint.

This study shows that Lgr3 mediates Dilp8-dependent growth coordination and developmental delay during Drosophila imaginal disc regeneration by regulating NOS activation in the prothoracic gland and CNS.