Adrian Halme

The paper shows ecdysone has a dual role in Drosophila regeneration, promoting it at low concentrations and suppressing it at high concentrations, coordinating regeneration with development.

The paper shows that ecdysone regulates the epithelial barrier in Drosophila imaginal discs, limiting Dilp8 signaling and controlling the duration of the regeneration checkpoint.

This study shows that Lgr3 mediates Dilp8-dependent growth coordination and developmental delay during Drosophila imaginal disc regeneration by regulating NOS activation in the prothoracic gland and CNS.

This study shows nitric oxide regulates growth coordination during Drosophila regeneration by modulating ecdysone biosynthesis in the prothoracic gland.