Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in LMNA-related dilated cardiomyopathy that are reversed by LINC complex disruption
Noam Zuela-Sopilniak, Julien L. P. Morival, Ioannis Ntekas, Margaret A. Elpers, Rohit Agarwal, Sarah J. Henretta, Jacob D. Odell, Iwijn De Vlaminck, Jan Lammerding
This study identifies NE rupture in LMNA-DCM cardiomyocytes as a driver of transcriptomic changes and immune activation, which can be reversed by LINC complex disruption.
bioRxiv · Jun 11, 2024 · PreprintCell Biology