Molecular determinants of extracellular TIMP-3 accumulation in Sorsby fundus dystrophy.
Jacob H. J. Betts, Katherine Hampton, Dudley K. Strickland, Simon J. Clark, Anthony J. Day, Linda Troeberg
This study identifies molecular mechanisms of TIMP-3 accumulation in Sorsby fundus dystrophy, showing differential endocytosis of mutant variants and implications for therapeutic strategies.
bioRxiv · May 19, 2025 · PreprintBiochemistry