Dudley K. Strickland

The paper shows that O-glycans in LRP1's ligand-binding domains differentially modulate uptake of tau and amyloid beta, but not RAP or ApoE.

This study identifies molecular mechanisms of TIMP-3 accumulation in Sorsby fundus dystrophy, showing differential endocytosis of mutant variants and implications for therapeutic strategies.

The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.

This study shows LRP1 and SORL1 internalize and degrade tau, while also facilitating its cytosolic seeding, suggesting their role in tau pathology spread in Alzheimer's disease.