Simon J. Clark

This paper develops CTx001, a gene therapy expressing mini-CR1, which reduces MAC formation in a rat model of geographic atrophy.

This study identifies molecular mechanisms of TIMP-3 accumulation in Sorsby fundus dystrophy, showing differential endocytosis of mutant variants and implications for therapeutic strategies.

This study shows that the CFH Y402H polymorphism increases vulnerability of iPSC-RPE cells to Hydroquinone-induced oxidative stress, suggesting genetic risk predisposition rather than soluble FH effects.

This study shows that mTOR inhibition with rapamycin partially rescues metabolic defects in RPE cells caused by CFH loss, suggesting a link between intracellular FH and the ubiquitin-proteasomal pathway.