Anthony J. Day

The paper introduces a high-throughput SPR array to profile GAG-protein interactions, validating it with known proteins and identifying new interactions.

This study shows that covalent attachment of heavy chains to hyaluronan protects it from ROS-induced fragmentation during inflammation.

This study identifies PCSK5A and GDF9 as key regulators of cumulus-oocyte-complex matrix integrity and cumulus cell migration during late ovulation, with implications for fertility therapeutics.

This study shows that blocking CD44, a hyaluronan receptor, reduces inflammation and improves survival in mice infected with SARS-CoV-2.

The paper investigates how intestinal tissues respond to joint inflammation in a rat model, finding region-specific transcriptomic and microbiome changes.

The paper generates a Ym1 deficient mouse using CRISPR-Cas9 in CB6 embryos and validates the absence of Ym1 protein without affecting related chitinase genes.

This study identifies molecular mechanisms of TIMP-3 accumulation in Sorsby fundus dystrophy, showing differential endocytosis of mutant variants and implications for therapeutic strategies.

This paper investigates how PTX3's quaternary structure enables HA crosslinking via interactions with HC1, revealing pH-dependent binding and structural flexibility.

This study chemically modifies HA oligosaccharides to differentially modulate their binding to HABPs, revealing structural insights into HA-receptor interactions.