Systematic loss of function screens identify pathway specific functional circular RNAs
Ling Liu, Matthew Neve, Laura Perlaza-Jiménez, Xinqi Xi, Jacob Purcell, Azelle Hawdon, Simon J. Conn, Jennifer Zenker, Pablo Tamayo, Gregory J. Goodall, Joseph Rosenbluh
The paper identifies pathway-specific functional circular RNAs through loss-of-function screens in cancer cell lines, revealing roles in ferroptosis, WNT, and MAPK signaling.
Nature Cell Biology · Aug 1, 2024Peer-reviewedGenetics