Xinqi Xi

The paper identifies SRP19 as a vulnerability in cancers with APC loss, showing that reducing SRP19 inhibits proliferation through ER stress.

The paper introduces SAM-DNMT3A, a CRISPR-based method to induce global DNA methylation, and shows it exploits a vulnerability in ER-positive breast cancers.

The paper identifies pathway-specific functional circular RNAs through loss-of-function screens in cancer cell lines, revealing roles in ferroptosis, WNT, and MAPK signaling.