Simon J. Conn

Engineering circular RNA expression systems to minimize contaminating linear RNA byproducts

This paper develops a system to produce high-purity circular RNAs by minimizing linear RNA byproducts through optimized circularization and transcript termination strategies.

Systematic loss of function screens identify pathway specific functional circular RNAs

The paper identifies pathway-specific functional circular RNAs through loss-of-function screens in cancer cell lines, revealing roles in ferroptosis, WNT, and MAPK signaling.

Versatile toolkit for highly-efficient and scarless overexpression of circular RNAs

The paper introduces a toolkit for efficiently and scarlessly overexpressing circular RNAs by redesigning plasmid vectors to eliminate molecular scars at back-splice junctions.