The Notch-Pdgfr beta axis suppresses brown adipocyte progenitor differentiation in early postnatal mice
Zuoxiao Shi, Shaolei Xiong, Ruoci Hu, Zilai Wang, Jooman Park, Yanyu Qian, Jaden Wang, Pratibha Bhalla, Nipun Velupally, Qing Song, Zhenyuan Song, Minsun Stacey Jeon, Ke Kurt Zhang, Linlin Xie, Brian Thomas Layden, , Yuwei Jiang
This study identifies PDGFRβ+ pericytes as developmental brown adipocyte progenitors and shows that inhibiting the Notch/PDGFRβ axis promotes brown adipogenesis and improves metabolic health.
Developmental Cell · Apr 2, 2024Peer-reviewedDevelopmental Biology