Brian Thomas Layden

This study shows that adding fermentable fiber to a Western diet reduces indole levels and improves gut microbiota diversity and metabolic health in mice.

This study identifies PDGFRβ+ pericytes as developmental brown adipocyte progenitors and shows that inhibiting the Notch/PDGFRβ axis promotes brown adipogenesis and improves metabolic health.

MiMeNet is a neural network framework that improves prediction of metabolite abundances and identifies microbe-metabolite interactions, outperforming linear models in paired microbiome-metabolome datasets.