Yuwei Jiang

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner

This study shows FoxO1 in the medial preoptic area (MPOA) influences metabolic adaptation to diet and temperature, with effects specific to female mice.

The Notch-Pdgfr beta axis suppresses brown adipocyte progenitor differentiation in early postnatal mice

This study identifies PDGFRβ+ pericytes as developmental brown adipocyte progenitors and shows that inhibiting the Notch/PDGFRβ axis promotes brown adipogenesis and improves metabolic health.

α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation

This study identifies α-ketoglutaric acid (AKG) as a metabolite that promotes muscle hypertrophy and fat loss via OXGR1-dependent adrenal activation in response to resistance exercise.