Spatial Metabolomics by Desthiobiotin Ligase (DESTNI) in Live Cells
Chang‐Mo Yoo, Jae-Yoon Jo, Chang-Ryul Choi, Ye Seop Park, Yun Jae Cha, Sungwoon Jung, Jiwoong Kang, Jeesoo Kim, Yun Pyo Kang, Tae Hyeon Yoo, Jong‐Seo Kim, Hyun‐Woo Rhee
This paper introduces DESTNI, a proximity labeling tool for spatial metabolomics, and demonstrates its application in identifying compartment-specific amino metabolite signatures in live cells.
bioRxiv · Jul 6, 2026 · PreprintBiochemistry