Yun Pyo Kang

Spatial Metabolomics by Desthiobiotin Ligase (DESTNI) in Live Cells

This paper introduces DESTNI, a proximity labeling tool for spatial metabolomics, and demonstrates its application in identifying compartment-specific amino metabolite signatures in live cells.

Endogenous nucleophilic scavengers of reactive acyl-species neutralize carbon stress

The paper identifies endogenous nucleophilic metabolites that neutralize reactive acyl species, reducing protein acylation and extending lifespan in model organisms.

Cell state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer

The paper identifies metabolic differences between ASCL1-high and low SCLC cells, showing that ASCL1-high cells resist ferroptosis via BH4/BH2 antioxidants and are vulnerable to combined cysteine depletion and BH4/BH2 inhibition.

Catabolism of extracellular glutathione supplies amino acids to support tumor growth

This study shows that extracellular glutathione supports tumor growth by providing amino acids through catabolism, and inhibiting this process slows tumor growth.

Targeting FSP1 triggers ferroptosis in lung cancer

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur thanks to the previously uncharacterized homocysteine synthase Yll058w

The paper shows that yeast cells lacking Met15 can assimilate inorganic sulfur via Yll058w, but require exogenous methionine or hydrogen sulfide chelators to grow, challenging the traditional view of MET15 as essential for sulfur assimilation.